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. 2022 Jul 29;10:55. doi: 10.1186/s40364-022-00400-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — TMB and UMS were used as biomarkers for docetaxel and atezolizumab stratification in the discovery cohort. Left Kaplan-Meier plots of OS in NSCLC patients receiving docetaxel when using the biomarkers bTMB, sbTMB and UMS. The optimal cut-off values of the three biomarkers were determined for stratification. OS curves of responders and non-responders are shown on the top left (bTMB, responders: n = 165; non-responders: n = 153), middle left (sbTMB, responders: n = 181; non-responders: n = 137), and bottom left (UMS, responders: n = 207; non-responders: n = 111). Right Kaplan-Meier plots of OS in NSCLC patients receiving atezolizumab when using the biomarkers bTMB, sbTMB and UMS. The cut-off values of the three biomarkers were set as follows: bTMB: ≤ 7 or > 20; sbTMB: ≤ 4 or > 17; and UMS ≤ 3. OS curves of responders and non-responders are shown on the top right (bTMB, responders: n = 129; non-responders: n = 195), middle right (sbTMB, responders: n = 147; non-responders: n = 177), and bottom right (UMS, responders: n = 102; non-responders: n = 222)