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. 2022 Jul 29;10:55. doi: 10.1186/s40364-022-00400-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Validation of the effectiveness of the TMI in the validation cohort (POPLAR cohort). A Top Kaplan-Meier plots of OS in NSCLC patients receiving docetaxel after TMI stratification. For responders, the median OS duration was 11.89 months (n = 54); for non-responders, the median OS duration was 6.70 months (n = 52). The HRs of all patients and the corresponding subgroups are shown on the top right. Bottom Kaplan-Meier plots of OS in NSCLC patients receiving atezolizumab after TMI stratification. For responders, the median OS duration was 15.77 months (n = 63); for non-responders, the median OS duration was 7.38 months (n = 42). The HRs of all patients and the corresponding subgroups are shown on the lower right. B Left Evaluation of clinical efficacy in patients defined as having a low TMI and a high TMI after receiving docetaxel monotherapy. Right Evaluation of clinical efficacy in patients defined as having a low TMI and a high TMI after receiving atezolizumab monotherapy. The blue pillar represents the survival time for each patient; the red circle represents those still alive at the end of the follow-up