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. 2022 Jul 28;14:96. doi: 10.1186/s13148-022-01316-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — IFNγ evokes a concerted transcriptional response in cancer. A RNA-seq of AT3 cells stimulated with IFNγ. B Normalized counts (log₂ counts per million) of IFNγ stimulated genes. C GSEA for AT3 cells stimulated with IFNγ. D Survival of breast cancer patients (from TCGA) stratified by expression of concordant IFNγ stimulated genes. E RNA polymerase II occupancy by ChIP-seq across IFNγ stimulated or non-IFNγ stimulated genes. F De novo motif analysis in promoters of IFNγ stimulated genes. G Distribution of IRF and ISRE motifs within promoters of IFNγ stimulated genes