Fig. 2.

Time to respiratory support including permanent ventilation*: ANCHOVY. *Time from birth to first occurrence of awake-assisted, night-time-assisted, or nap-time-assisted ventilation, airway clearance through cough assistance or permanent ventilation (defined as ≥ 16 h of non-invasive ventilation per day for > 21 consecutive days, intubation for > 21 consecutive days, or tracheostomy). 90% CIs are calculated with a complementary log–log transformation for the estimated survival function, with standard errors computed via Greenwood’s formula. Patients with no recorded events are censored at the last age they were known to be event free. One additional patient required respiratory support after 24 months of age. CI, confidence interval