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. Author manuscript; available in PMC: 2022 Jul 29.
Published in final edited form as: Front Dent Med. 2022 Apr 28;3:846962. doi: 10.3389/fdmed.2022.846962

FIGURE 2 |.

FIGURE 2 |

TNAP and ENPP1 ablation effects on body and craniofacial measurements. Total body weight (A), body length (B), and skull length (C) for single mutant, double mutant and wild type postnatal day 17 mice are shown. Skull measurements normalized to skull length to account for differences in skull/mouse size for single mutant, double mutant and wild type postnatal day 17 mice are shown (D–J). TNAP−/−/ENPP1+/+ mice are significantly diminished in body weight, body length and skull size, and exhibit skull shape abnormalities when compared to TNAP+/+/ENPP1+/+ mice. TNAP−/−/ENPP1−/− mice show significantly greater body weight, body length, skull length with improvements in skull shape, when compared to TNAP−/−/ENPP1+/+ mice. *p < 0.05 vs. TNAP+/+/ENPP1+/+ mice, ***p < 0.005 vs. TNAP+/+/ENPP1+/+ mice, #p < 0.05 vs. TNAP−/−/ENPP1+/+ mice, ###p < 0.005 vs. TNAP−/−/ENPP1+/+ mice.