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. 2022 Jul 15;13:931501. doi: 10.3389/fphar.2022.931501

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Copyright © 2022 Xu, Liang, Liu and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAB39B was associated with DLBCL cell proliferation, apoptosis, and drug sensitivity in vitro. (A) RAB39B siRNA transfection efficiency in U2932 and OCI-LY7 was measured by qPCR. (B) CCK-8 proliferation assay showed that RAB39B inhibition resulted in decreased proliferation of U2932 and OCI-LY7 DLBCL cells. (C) Inhibition of RAB39B resulted in increased apoptosis in U2932 (18.79%) and OCI-LY7 (16.84%) DLBCL cells. (D) Inhibition of RAB39B significantly increased the sensitivity of DLBCL cells to doxorubicin and vincristine.