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. 2022 Jul 29;5:766. doi: 10.1038/s42003-022-03700-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Over 205,000 publicly available antibody sequences were retrieved from GenBank and supplementary files of previous publications reporting human anti-SARS-CoV-2 antibodies. The compiled antibody sequence library consists of 72% heavy chains (IGH), 16.4% kappa chains (IGK), and 11.7% lambda chains (IGL). CDR3 amino-acid sequences were used to search for the YYDRxG motif with five or more amino acid residues prior and seven or more amino acid posterior to the hexad motif. 153 heavy chain sequences were identified that contain a YYDRxG pattern and followed by data curation with literature review. 65% (100) are antibodies isolated from COVID-19 patients and mRNA vaccinees. 28 (18%) have been validated for SARS-CoV-2 neutralization (Neut. tested), while 72 (47%) have not (sequences only). b YYDRxG antibodies are mostly encoded by the IGHD3-22 gene. All of the D genes used by YYDRxG antibodies were counted. Numbers at the right side of each bar indicate the percent of the total of identified YYDRxG antibodies. c IGHD3-22 encodes all YYDRxG antibodies against SARS-CoV-2. All 100 sequences of anti-SARS-CoV-2 antibodies were analyzed and counted. d, e Heavy chain variable (d IGHV) and joining (e IGHJ) genes of YYDRxG antibodies isolated from COVID-19 patients or vaccinees. A diverse but limited set of variable and joining genes pair with IGHD3-22 in YYDRxG antibodies against SARS-CoV-2. IGHV3-30, IGHV4-39, IGHV3-33, and IGHV1-69 are more frequently found than others. Arrows indicates the immunoglobulin genes that encode ADI-62113 in this study.