. 2022 Jul 11;8(7):1028–1034. doi: 10.1021/acscentsci.2c00204

Table 1. Optimization of the Reaction Conditions^a.

entry	variations from standard conditions	yield^b
1	None	88%
2	No FeCl₃	N.D^c
3	No HOAc	N.D^c
4	FeCl₂ instead of FeCl₃	71%
5	FeBr₃ instead of FeCl₃	81%
6	Fe(acac)₃ instead of FeCl₃	11%
7	Fe(NO₃)₃ instead of FeCl₃	7%
8	CuBr instead of FeCl₃	6%
9	AgOAc instead of FeCl₃	10%
10	10 mol % of FeCl₃	72%

Reaction conditions: 1a (0.2 mmol), 2a (2.0 equiv), FeCl₃ (20 mol %), HOAc (10.0 equiv), and EtOAc (2.0 mL) at r.t. under Ar for 8 h. The d.r. of 3a was about 9:1.

Isolated yields.

N.D. = Not detected.

Table 1. Optimization of the Reaction Conditionsa.

Table 1. Optimization of the Reaction Conditions^a.