Table 1.

Factors affecting mitochondrial function during sepsis

	Classification	Factors	Effect on mitochondria	References
Relative hypoxia	Macrocirculation	Volume distribution	oxygen delivery	De Backer et al. [116] Lin et al. [118]
		Cardiac function
		Vascular tone
	Microcirculatory	Glycocalyx degradation	O2 diffusion distance	De Backer et al. [116] Inkinen et al. [117]
		Endothelial dysfunction
Oxygen utilization disorder	Mitochondrial homeostasis	PGC-1α, Tfam, NRF1	Biogenesis	Mao et al. [129] Tran et al. [130]
		Drp1, Mff	Fission	Seabright et al. [134]
		Mfn1/2, OPA1	Fusion	Zhang et al. [136]
		PINK, Parkin, FUNDC1	Autophagy	Zhang et al. [131]
	Regulatory molecules	HIF-1α, GR, PPAR-α	PDC activity	Dasgupta et al. [121] Connaughton et al. [122] Palomer et al. [123] Nakamura et al. [124]
		SIRT1	FAO, Biogenesis	Kitada et al. [146]
		AMPK	Mitochondrial homeostasis	Herzig et al. [133] Seabright et al. [134]
		CaMK-IV	ΔΨm, fission, fusion, autophagy	Zhang et al. [136]
		UCP2	ΔΨm, ROS	Mao et al. [129] Donadelli et al. [135]
		RIPK3	Autophagy	Zhou et al. [132]
		NO, H2S, ROS	PDC activity, TCA cycle, ETC complexes	Brown et al. [125] Erika et al. [126] Murphy et al. [127] Zorov et al. [128]
	Hormone	Thyroid hormones	Biogenesis autophagy	Yu et al. [141] Marín-García et al. [142] Yau et al. [143]
		Insulin	OXPHOS	Szendroedi et al. [144] Tubbs et al. [145]