Table 2.

Top differentially expressed genes from the meta-analysis of atopy

		EVA-PR			BAMSE			Meta-analysis
Gene Symbol	Description	Fold Change	P Value	FDR	Fold Change	P Value	FDR*	Fold Change	P Value	FDR
SIGLEC8	Sialic acid binding Ig like lectin 8	1.18	2.97×10−12	2.51×10−08	1.05	9.34×10−03	NS	1.10	8.07×10−13	2.86×10−08
IL5RA	Interleukin 5 receptor subunit alpha	1.15	2.06×10−09	3.48×10−06	1.18	1.97×10−04	NS	1.16	2.03×10−12	3.59×10−08
IL17RB	Interleukin 17 receptor B	1.19	1.29×10−14	2.18×10−10	1.01	2.39×10−01	NS	1.04	5.14×10−12	6.07×10−08
SLC29A1	Solute carrier family 29 member 1 (Augustine blood group)	1.15	1.23×10−09	2.31×10−06	1.05	9.24×10−04	NS	1.07	7.07×10−12	6.26×10−08
SMPD3	Sphingomyelin phosphodiesterase 3	1.15	2.44×10−10	1.03×10−06	1.04	5.31×10−03	NS	1.07	1.48×10−11	1.05×10−07
IL1RL1	Interleukin 1 receptor like 1	1.14	6.15×10−09	8.94×10−06	1.13	2.24×10−03	NS	1.14	8.46×10−11	4.99×10−07
ALOX15	Arachidonate 15-lipoxygenase	1.15	9.79×10−10	2.11×10−06	1.11	1.22×10−02	NS	1.14	1.48×10−10	7.50×10−07
OLIG2	Oligodendrocyte transcription factor 2	1.17	5.22×10−12	2.×10 −08	1.01	3.18×10−01	NS	1.06	7.96×10−10	3.52×10−06
PIK3R6	Phosphoinositide-3-kinase regulatory subunit 6	1.12	9.07×10−08	7.×10 −05	1.05	2.41×10−03	NS	1.07	1.04×10−09	4.10×10−06
CLC	Charcot-Leyden crystal galectin	1.14	2.54×10−08	2.×10 −05	1.17	9.22×10−03	NS	1.14	1.65×10−09	5.85×10−06
ADORA3	Adenosine A3 receptor	1.14	6.58×10−09	8.94×10−06	1.04	2.47×10−02	NS	1.07	1.95×10−09	6.27×10−06
CEBPE	CCAAT/enhancer binding protein epsilon	1.12	1.04×10−06	6.04×10−04	1.07	2.32×10−03	NS	1.09	9.52×10−09	2.59×10−05
PMP22	Peripheral myelin protein 22	1.15	1.00×10−09	2.11×10−06	1.02	1.75×10−01	NS	1.06	1.05×10−08	2.66×10−05
PRSS33	Protease, serine 33	1.15	7.21×10−10	2.03×10−06	1.01	3.15×10−01	NS	1.05	2.77×10−08	6.55×10−05
PTGDR2	Prostaglandin D2 receptor 2	1.12	3.85×10−07	2.60×10−04	1.04	2.34×10−02	NS	1.07	5.61×10−08	1.17×10−04
RAB44	Member RAS oncogene family	1.08	6.77×10−05	2.11×10−02	1.07	2.39×10−04	NS	1.07	7.15×10−08	1.41×10−04
HRASLS5	HRAS like suppressor family member 5	1.14	2.11×10−08	2.19×10−05	1.02	1.60×10−01	NS	1.05	9.10×10−08	1.69×10−04
HRH4	Histamine receptor H4	1.11	4.78×10−06	2.18×10−03	1.10	7.45×10−03	NS	1.11	1.37×10−07	2.42×10−04
CCR3	C-C Motif Chemokine Receptor 3	1.11	1.20×10−05	4.72×10−03	1.15	4.20×10−03	NS	1.11	1.77×10−07	2.85×10−04
CDK15	Cyclin dependent kinase 15	1.14	8.22×10−09	9.25×10−06	1.01	3.56×10−01	NS	1.03	2.14×10−07	3.29×10−04

All models were adjusted for age, sex, asthma status, batch, and proportions of white blood cell subtypes (eosinophils, lymphocytes, neutrophils and monocytes). Models in EVA-PR were additionally adjusted for principal components.

^*NS means non-significant, i.e., FDR-adjusted P value > 0.05.