Figure 2.

Tip60 protects against early (third-instar larval) and late (seven-day-old adult) transcriptomic deregulation in the APP AD-associated neurodegenerative brain. (a) Log2 fold changes of differentially expressed genes (padj ≤0.05 and log2FoldChange of ≤-0.583 and ≥0.583) determined by RNA-seq in the third-instar larval and adult heads in APP vs. w¹¹¹⁸ and APP;Tip60 vs. APP. Changes were prominent in both third-instar larval and adult APP heads, while Tip60-induced changes initiated in the third-instar larval head and were prominent in the adult head: indicating the effect of Tip60 over time. (b and c) The upSet plot represents the distribution and intersection of down and up-regulated genes between APP vs. w¹¹¹⁸ and APP;Tip60 vs. APP in third-instar larval (b) and adult (c) heads. Rows represent the number of genes in each comparison (APP vs. w¹¹¹⁸ and APP;Tip60 vs. APP), and columns represent the number of genes per interaction. The red and blue bars represent the up and down-regulated genes, respectively. The black filled dots indicate the association between rows. The red and blue columns represent genes uniquely up-regulated and down-regulated genes, respectively, in given comparisons, while the purple columns represent Tip60 reprogrammed genes.