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. 2016 Apr 30;24(3):620–626. doi: 10.1016/j.jfda.2016.02.008

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© 2016 Taiwan Food and Drug Administration

This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Precultured 4T1 cells were injected into Balb/c mice in different groups and then mice splenocyte cytokine release was evaluated on Day 35. (A and B) While there were no differences of cytokine secretion in two-dimensional (2D) and 3D precultures (p > 0.05), (A and B) preradiation of 4T1 cells caused enhanced interferon-gamma (IFN-γ) and reduced interleukin-4 (IL-4) release in 2D culture conditions in comparison with 3D precultures. (C and D) there were no differences of cytokine secretion in two-dimensional (2D) and 3D precultures regarding IL-10 and TGF-β cytokines. IL-10 = interleukin-10; radi = radiation; Scaff = scaffold; SD = standard deviation; TGF-β = transforming growth factor beta, ^*: p < 0.05.