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. 2022 Jul 15;3:926627. doi: 10.3389/fragi.2022.926627

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Copyright © 2022 Tong, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RPE changes during aging: Young RPE cell shows elongated microvilli, tight contact with nearby cells, containing plenty of mitochondria, melanin granules and photoreceptor fragments. Aged RPE cell shows larger size, multinucleation, shortened microvilli, decreased mitochondria numbers, loss of melanin granules, decreased phagocytosis, accumulation of lipofuscin and iron, basal laminar deposits, increased BrM thickness and accumulation of drusen.