Table 1.
Chromatographic parameters of profen enantioseparation at various concentrations of buffer solution with mobile phase: MeOH/KH2PO4 (pH 4.5); 50/50 (v/v); flow rate: 0.5 mL/min.
| Profen | 0.02 M | 0.04 M | 0.10 M | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| k1′ | k2′ | Rs | α | k1′ | k2′ | Rs | α | k1′ | k2′ | Rs | α | |
| Ketoprofen | 6.5 | 9.7 | 1.74 | 1.42 | 5.1 | 7.4 | 1.88 | 1.38 | 3.6 | 5.3 | 1.75 | 1.38 |
| Ibuprofen | 3.9 | 6.0 | 1.03 | 1.42 | 2.8 | 4.2 | 1.25 | 1.36 | 1.8 | 2.7 | 0.93 | 1.31 |
| Indoprofen | 8.6 | 14.1 | 2.14 | 1.58 | 4.7 | 7.5 | 1.71 | 1.50 | 4.3 | 6.7 | 1.74 | 1.46 |
| Fenoprofen | 7.1 | 9.1 | 0.79 | 1.24 | 4.9 | 6.2 | 1.08 | 1.22 | 3.2 | 4.0 | 0.82 | 1.19 |
| Flurbiprofen | 9.8 | 17.9 | 1.83 | 1.74 | 6.4 | 11.4 | 2.05 | 1.67 | 4.2 | 7.4 | 1.59 | 1.60 |
α = selectivity; k = capacity factors; Rs = resolution.