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. 2022 Jul 27;42(30):5860–5869. doi: 10.1523/JNEUROSCI.2141-21.2022

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Figure 8. — Expression of OL differentiation genes is downregulated in Secisbp2l-CKO mice. A, Volcano plot of differentially expressed genes. A value of 303 was assigned for -Log₁₀(pValue) larger than 302 (Extended Data Fig. 8-1). B, Expression of OL differentiation genes and myelin-related genes was significantly enriched in downregulated genes as revealed by gene ontology analysis in Secisbp2l-CKO mice. C, Expression analysis of pan OL lineage cell (Pan-OL), OL precursor cell (OPC), newly formed OL (NFO), and mature OL (MO) markers. D, Gene ontology analysis of the downregulated genes in Secisbp2l mutants. Glial cell development and lipid metabolism were the most affected biological processes.