Scheme 1. (a) Illustration of the formation of WP5⊃G nanoparticles by self-assembly of WP5 with G and the pH responsiveness of WP5⊃G. (b) Illustration of hierarchical self-assemblies to obtain WP5⊃G–siRNA supramolecular nanovesicles and the pH release of siRNA for intracellular therapy.