Figure 1.

Cognitive and biomarker data harmonization and cognitive resilience model. Memory, executive function, and Preclinical Alzheimer Cognitive Composite (PACC) scores were harmonized across cohorts. Additionally, in vivo amyloid PET SUVRs were harmonized with Gaussian mixture modelling. (A) Harmonized in vivo amyloid PET SUVR by harmonized memory scores are plotted by sex. (B) Linear models leveraging harmonized cognitive and amyloid data (harmonized in vivo PET or autopsy measures of amyloid plaque burden, CERAD scores) were residualized and fed as indicators into a residual cognitive resilience latent variable model. The combined resilience latent variable model included educational attainment as an additional indicator.