Table 2.
SNP-heritability estimates by sex
| Both sexes | Males | Females | Sex differences test | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| h2 | h2(SE) | P-value | h2 | h2(SE) | P-value | h2 | h2(SE) | P-value | Z-score | P-value | |
| Residual Cognitive Resilience | 4.16% | 4.75% | 0.11 | 7.65% | 9.09% | 0.10 | 5.61% | 10.60% | 0.31 | −0.15 | 0.88 |
| Residual Cognitive Resilience (CN) | 20.90% | 5.48% | 6.80 × 10−11 | 25.82% | 11.60% | 5.07 × 10−5 | 27.17% | 9.86% | 1.24 × 10−4 | 0.09 | 0.93 |
| Combined Resilience | 19.71% | 8.89% | 0.01 | 29.42% | 19.48% | 0.03 | 0.0001% | 14.50% | 0.50 | −1.21 | 0.23 |
| Combined Resilience (CN) | 25.25% | 7.95% | 2.33 × 10−7 | 44.11% | 18.64% | 9.57 × 10−5 | 14.93% | 12.37% | 0.06 | −1.30 | 0.19 |
CN = cognitively normal. h2 values are the V(G)/Vp estimates calculated from the GCTA restricted maximum likelihood statistical method (with genetic relatedness matrices). Sex differences test P-values were generated from the normal distribution based on a one-tailed test.