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. 2021 Dec 16;145(7):2472–2485. doi: 10.1093/brain/awab437

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Top hub genes from the coexpression analyses of FTLD-TDP-A with and without GRN mutation. (A) Top 20 hub genes for the green module are displayed. (B) Top 20 hub genes for the purple module are displayed. (C) Top 20 hub genes for the turquoise module are displayed. The size of the node is proportional to the connectivity of the gene. The strength of the correlation between two genes (nodes) is reflected by the thickness of the edge. Hierarchical GO analysis of biological process terms is presented on the right. Upregulated genes are circled in red and downregulated genes in blue. The main hub gene is coloured in yellow. Hierarchical GO analysis of biological process terms is presented on the right.