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. 2022 Jul 15;13:908482. doi: 10.3389/fgene.2022.908482

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Copyright © 2022 Chen, Wang, Wang, Hu, Zhan, Zeng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Burden and trends of Down syndrome globally and in five SDI quintiles from 1990 to 2019. (A) Incident cases. (B) Prevalent cases. (C) Disability-adjusted life-years (DALYs). (D) Deaths. Black bars represent males, and red bars represent females. Note: DALYs, disability-adjusted life-years; SDI, social-demographic index.