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. 2022 Jul 15;13:908482. doi: 10.3389/fgene.2022.908482

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Copyright © 2022 Chen, Wang, Wang, Hu, Zhan, Zeng and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Estimated annual percentage changes of Down syndrome in 204 countries and territories between 1990 and 2019. (A) EAPC of age-standardized incident rates (ASIRs). (B) EAPC of age-standardized prevalent rates (ASPRs). (C) EAPC of age-standardized disability-adjusted life-year (DALY) rates. (D) EAPC of age-standardized death rates (ASDRs). Note: DALYs, disability-adjusted life-years; EAPC, estimated annual percentage changes.