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Association between ASRs of Down syndrome and SDI in 21 regions from 1990 to 2019. The SDI was positively correlated with the ASIR (A) and ASPR (B) in 21 regions from 1990 to 2019. The SDI was negatively correlated with the age-standardized DALY rate (C) and ASDR (D). Note: ASRs, age-standardized rates; ASIR, age-standardized incident rate; ASPR, age-standardized prevalent rate; ASDR, age-standardized death; DALYs, disability-adjusted life-years; SDI, social-demographic index.
