Figure 3.

Treatment with selonsertib, enalapril, or combination leads to differential gene ontology response in CKD progression. 5/6 Nx rats were biopsied and randomized to treatment groups (n=9–12 animals per group) at week 8 and euthanized at week 12. (A) Preparation of samples for RNA-sequencing (RNA-seq) analysis. (B) Longitudinal comparisons. (C) Number of genes modified by each treatment. (D) Genes specifically modified by the combination treatment. (E) Significantly affected molecular pathways. FC, fold change; FFPE, formalin-fixed paraffin-embedded; SEL, selonsertib.