Table 1.
Functional parameters at week 0 and week 12
| Parameter | Week 0 | Week 8 | Week 12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | ACEI | ACEI+SEL | SEL | Control | ACEI | ACEI+SEL | SEL | Control | ACEI | ACEI+SEL | SEL | |
| SBP, mm Hg | 123.8±3.8 | 118.9±3.5 | 122.1±2.3 | 122.2±4.0 | 202.6±10.9 | 200.0±9.0 | 194.0±7.8 | 201.0±6.7 | 210.4±8.5 | 175.0±9.2a,b | 170.5±9.3a | 184.7±9.2 |
| Body weight, g | 329.1±2.5 | 340.4±4.9 | 328.0±5.3 | 347.1±8.8 | 367.5±9.1 | 373.5±9.9 | 364.4±12.3 | 390.5±10.4 | 394.6±10.9c | 418.3±7.9b | 396.4±9.0d | 416.3±10.9e |
| UACR, µg/mg | 4.3±0.7 | 3.3±0.6 | 4.5±0.9 | 3.1±0.3 | 55.5±11.9 | 75.7±15.7 | 80.1±35.2 | 62.4±15.7 | 144.6±27.1c | 110.2±28.3 | 71.6±15.8a | 125.4±19.7e |
| Scr, mg/dl | 0.24±0.02 | 0.23±0.03 | 0.25±0.03 | 0.28±0.03 | 0.44±0.06 | 0.45±0.06 | 0.79±0.16 | 0.78±0.09 | 0.72±0.05c | 0.69±0.09b | 0.74±0.13 | 0.81±0.09 |
| Ccr, ml/min per 100 g body wt | 0.70±0.07 | 0.86±0.12 | 0.81±0.13 | 0.61±0.06 | 0.60±0.07 | 0.52±0.07 | 0.45±0.09 | 0.31±0.03 | 0.28±0.02c | 0.29±0.03b | 0.30±0.03 | 0.29±0.05 |
Data are shown as mean±SEM. n=9–12 animals per group. ACEI, angiotensin-converting enzyme inhibitor; SEL, selonsertib; SBP, systolic BP; UACR, urine albumin-creatinine ratio; Scr, serum creatinine; Ccr, creatinine clearance.
a
P<0.05 versus control at week 12.
b
P<0.05 versus ACEI at week 8.
c
P<0.05 versus at baseline (week 0).
d
P<0.05 versus ACEI+SEL at week 8.
e
P<0.05 versus SEL at week 8.