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Suggested model. In uninduced stromal progenitors (OFF state), Tcf21 binds β-catenin in the cytoplasmic destruction complex, preventing its degradation and thus facilitates β-catenin stabilization in the cytoplasm. Upon interstitial progenitor cell induction by Wnt9b (ON), Tcf21 accompanies β-catenin to the nucleus and enhances its transcriptional actions on TCF/LEF.
