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. 2022 May 16;18(8):821–830. doi: 10.1038/s41589-022-01024-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a. Upregulated gene sets enriched in Hs578-T cell after MS023 treatment for 5 days. Gene sets associated with immune response are red (one-tailed Fisher’s exact test). b. Quantification of cytoplasmic dsRNA signal intensity in MDA-MB-468 cells with indicated compound or shPRMT1 for 5 days (means±s.d., n = 3 independent biologically experiments of at least 91 cells per group analyzed). c. Quantification of cytoplasmic dsRNA signal intensity in HCC1143 cells with indicated compound treatment for 5 days (means±s.d., n = 3 independent biologically experiments of at least 70 cells per group analyzed). d. Quantification of cytoplasmic dsRNA signal intensity in SUM149-PT cells with indicated compound treatment for 5 days (means±s.d., n = 3 independent biologically experiments of at least 70 cells per group analyzed). e. Images of cellular dsRNA staining in Hs578-T cell after MS023 treatment for 5 days. Scale bar represents 10 μm (Representative images of 3 independent experiments are shown). f. Quantification of cytoplasmic dsRNA signal intensity in Hs578-T cell after MS023 treatment for 5 days (means±s.d., n = 3 of at least 40 cells per group analyzed, one-way ANOVA with Dunnett’s test). g. Quantification of cytoplasmic dsRNA signal intensity in Hs578-T cells with indicated compound or shPRMT1 for 5 days (means±s.d., n = 3 independent biologically experiments of at least 45 cells per group analyzed). h. Quantification of cytoplasmic dsDNA signal intensity in MDA-MB-468 cells with indicated compound treatment for 5 days (means±s.d., n = 3 independent biologically experiments of at least 120 cells per group analyzed). i. Quantification of cytoplasmic dsDNA signal intensity in Hs578-T cells with indicated compound treatment for 5 days (means±s.d., n = 3 independent biologically experiments of at least 43 cells per group analyzed). For panels b-d, and g-i, P values were calculated using one-way ANOVA with Dunnett’s test for multiple comparisons.

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