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. 2022 May 16;18(8):821–830. doi: 10.1038/s41589-022-01024-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a. Correlation of MTAP expression and MS023 sensitivity. b. Oncoplot showing the mutation status of genes involved in RNA splicing across TNBC cell lines. Color indicates different mutation type. Arrow indicates the sensitivity of cell lines to MS023 treatment. c. PRMT5 gene expression in the Princess Margaret Hospital cell line datasets (PM-Cell lines) datasets. Gene expression is reported as log₂(TPM + 0.001). d. PRMT5 protein expression in TNBC cell lines. Arrow indicates the sensitivity of cell lines to MS023 treatment. e. Correlation of cell doubling time and MS023 sensitivity.

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