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. 2022 Jul 29;8:89. doi: 10.1038/s41523-022-00455-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Changes in α-diversity measures of the 28 participants who provided all four samples before AC-D, during AC, during D and after AC-D treatment, measured in terms of observed species richness (p = 0.042; n = 28) and Shannon index (p = 0.206; n = 28) (Supplementary Table 5). B Pairwise comparison (Wilcoxon signed-rank sum test with Bonferroni correction) of all samples before AC-D (n = 44), during AC (n = 43), during D (n = 29) and after AC-D treatment (n = 37) revealed significant differences in observed species richness between T0-T3 (p = 0.003; n = 37) (Supplementary Table 6). The boxplot in Fig. 3B shows the medians, IQR’s, minimum, maximum and an outlier.