Table 2.

Time trend changes of blood-based biomarkers in patients with septic shock according to survivor and non-survivor groups.

Groups	Time trends				Time interaction		Time * group interaction
	Baseline	6 h	12 h	24 h	Unadjusted (P value)b	Adjusted (P value)c	Unadjusted (P value)d	Adjusted (P value)e
Lactate/albumin
Survivors	0.149 ± 0.036	–	–	–	–	–	–	–
Non-survivors	0.259 ± 0.053	–	–	–	–	–	–	–
P valuea	< 0.001*
Lactate
Survivors	3.94 ± 0.248	3.17 ± 0.267	2.58 ± 0.330	2.05 ± 0.299	< 0.001*	0.734	< 0.001*	< 0.001*
Non-survivors	3.93 ± 0.612	3.35 ± 0.546	3.05 ± 0.559	2.82 ± 0.480
P valuea	0.897	0.010*	< 0.001*	< 0.001*
Lactate clearance
Survivors	–	19.39 ± 6.14	34.43 ± 8.08	47.87 ± 7.89	< 0.001*	0.327	< 0.001*	< 0.001*
Non-survivors	–	15.05 ± 5.92	22.14 ± 9.42	27.61 ± 7.75
P valuea		< 0.001*	< 0.001*	< 0.001*

*P < 0.05 considered as significant.

^aP value based on t-test between groups.

^bUnadjusted P value based on time interaction in repeated measures ANOVA.

^cAdjusted P value (adjusting for age, gender, comorbidities, SOFA and APACHE IV) based on time interaction in repeated measures ANOVA.

^dUnadjusted P value based on time * group interaction in repeated measures ANOVA.

^eAdjusted P value (adjusting for age, gender, comorbidities, SOFA and APACHE IV) based on time * group interaction in repeated measures ANOVA.