Table 3.

Univariate and multivariate logistic regression analysis to determine the effect of baseline characteristics and biomarkers on mortality and MV duration.

Variables	Univariate		Multivariate
	OR (95% CI)	P value	OR (95% CI)	P value
Mortality (yes vs. no)
Age	0.957 (0.909–1.007)	0.090	1.145 (1.007–1.303)	0.039*
Gender (female vs. male)	0.787 (0.4–1.546)	0.487	–	–
Comorbidity (yes vs. no)	6.613 (1.512–28.918)	0.012*	3.821 (1.302–11.213)	0.015*
APACHE IV	1.463 (1.253–1.708)	< 0.001*	–	–
SOFA	2.545 (1.813–3.572)	< 0.001*	2.674 (1.271–5.624)	0.01*
Multiple organ failure (yes vs. no)	7.000 (3.289–14.9)	< 0.001*	4.179 (1.069–8.312)	< 0.001*
Blood culture (yes vs. no)	0.920 (0.461–1.836)	0.814	–	–
ICU length of stay	1.280 (1.135–1.443)	< 0.001*	1.634 (1.135–4.243)	0.002*
Duration of MV	1.733(1.426–2.106)	< 0.001*	1.928 (1.105–3.363)	0.021*
Duration of using vasopressor	4.538 (2.483–8.295)	< 0.001*	3.753 (2.446–5.759)	< 0.001*
RRT (yes vs. no)	0.376 (0.173–0.816)	0.013*	–	–
Lactate/Albumin	1.04 × 1018 (5.85 × 1012–84 × 1023)	< 0.001*	7.57 × 1018 (11,049.220–5.19 × 1023)	0.003*
Lactate baseline	0.946 (0.413–2.166)	0.896	–	–
Lactate at 6 h	3.468 (1.312–9.168)	0.012*	4.459 (0.158–125.51)	0.381
Lactate at 12 h	6.375 (4.467–8.963)	< 0.001*	2.786 (0.077–10.678)	0.576
Lactate at 24 h	9.628 (2.767–10.763)	< 0.001*	12.621 (4.833–14.944)	< 0.001*
Clearance lactate at 6 h	0.879 (0.82–0.942)	< 0.001*	0.972 (0.858–1.102)	0.66
Clearance lactate at 12 h	0.857 (0.812–0.905)	< 0.001*	0.964 (0.834–1.114)	0.619
Clearance lactate at 24 h	0.731 (0.655–0.815)	< 0.001*	0.721 (0.608–0.854)	< 0.001*
MV duration (≥ 6 days vs. < 6 days)
Age	0.976 (0.921–1.033)	0.395	–	–
Gender (female vs. male)	0.618 (0.302–1.264)	0.187	–	–
Comorbidity (yes vs. no)	7.856 (0.995–10.122)	0.998	–	–
APACHE IV	1.335 (1.158–1.538)	< 0.001*	0.977 (0.533–1.79)	0.940
SOFA	1.883 (1.377–2.575)	< 0.001*	1.255 (1.361–4.367)	0.021*
Multiple organ failure (yes vs. no)	11.2 (3.742–33.522)	< 0.001*	0.529 (0.089–3.126)	0.482
Blood culture (yes vs. no)	1.546 (0.757–3.161)	0.232	–	–
ICU length of stay	4.005 (2.431–6.6)	< 0.001*	4.547 (2.282–9.061)	< 0.001*
RRT (yes vs. no)	5.831 (1.682–20.214)	0.005*	0.371 (0.025–5.511)	0.471
Duration of using vasopressor	4.118 (2.478–6.845)	< 0.001*	2.522 (1.203–5.289)	0.014*
Lactate/Albumin	1.41 × 1013 (22,546,848.8–8.90073 × 1018)	< 0.001*	6.03 × 1013 (1.918 × 1016–10.89 × 1016)	0.003*
Lactate baseline	1.084 (0.459–2.561)	0.854	0.835 (0.118–5.894)	0.857
Lactate at 6 h	2.018 (0.805–5.056)	0.134	0.248 (0.023–2.676)	0.251
Lactate at 12 h	4.209 (1.718–10.316)	0.002	0.269 (0.019–3.873)	0.335
Lactate at 24 h	10.10 (3.533–28.869)	< 0.001*	18.83 (1.416–25.406)	0.026*
Clearance lactate at 6 h	0.949 (0.897–1.004)	0.070	1.074 (0.978–1.179)	0.136
Clearance lactate at 12 h	0.926 (0.885–0.968)	0.001*	1.041 (0.94–1.153)	0.441
Clearance lactate at 24 h	0.911 (0.875–0.948)	< 0.001*	0.891 (0.804–0.988)	0.029*

OR odds ratio, CI confidence interval.

*P < 0.05 considered as significant.