Table 1.
Demographic characteristics of adults enrolled in the single-centre DeNoPa and multi-centric PPMI (and FOUND) cohorts.
| DeNoPa | PPMIa | FOUNDa | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Case | Control | p | Case | Control | p | Case | Control | p | |
| No. of participants | 135 (55.1) | 110 (44.9) | 428 (68.59) | 196 (31.41) | 141 (65.28) | 75 (34.72) | |||
| Male | 88 (65.19) | 67 (60.91) | 0.49 | 280 (65.42) | 126 (64.29) | 0.78 | 94 (66.67) | 51 (68) | 0.84 |
| Age at baseline, years | 66 (40–84) | 65.5 (44–84) | 0.85 | 63 (34–85) | 62.5 (31–84) | 0.52 | 61 (36–82) | 60 (31–80) | 0.74 |
| Male | 66 (40–82) | 67 (44–84) | 0.69 | 63 (35–85) | 63 (31–83) | 0.69 | 63 (36–79) | 61 (31–80) | 0.64 |
| Female | 66 (41–84) | 64 (51–74) | 0.51 | 61 (34–82) | 60 (31–84) | 0.61 | 56 (39–82) | 56 (32–71) | 0.74 |
| 10-year age brackets, No. (%) | |||||||||
| <40 | 0 (0) | 0 (0) | 12 (2.8) | 8 (4.08) | 3 (2.13) | 3 (4) | |||
| 40–50 | 8 (5.93) | 2 (1.82) | 37 (8.64) | 21 (10.7) | 17 (12.1) | 8 (10.7) | |||
| 50–60 | 35 (25.9) | 22 (20) | 113 (26.4) | 54 (27.6) | 45 (31.9) | 26 (34.7) | |||
| 60–70 | 45 (33.3) | 57 (51.8) | 171 (40) | 68 (34.7) | 54 (38.3) | 23 (30.7) | |||
| 70–80 | 41 (30.4) | 28 (25.4) | 87 (20.3) | 38 (19.4) | 21 (14.9) | 14 (18.7) | |||
| 80+ | 6 (4.44) | 1 (0.91) | 8 (1.87) | 7 (3.57) | 1 (0.71) | 1 (1.33) | |||
| Hoehn and Yahr Stage | UPDRS | MDS UPDRS | MDS UPDRS | ||||||
| 0 | 0 (0) | 110 (100) | 0 (0) | 193 (98.5) | 0 (0) | 75 (100) | |||
| 1 | 33 (24.4) | 189 (44.2) | 2 (1.02) | 68 (48.2) | |||||
| 1.5 | 40 (29.6) | n.a. | n.a. | ||||||
| 2 | 25 (18.5) | 237 (55.4) | 72 (51.1) | ||||||
| 2.5 | 26 (19.3) | n.a. | n.a. | ||||||
| 3 | 11 (8.15) | 2 (0.467) | 1 (0.709) | ||||||
aFor PPMI and FOUND data, only participants classified as “Parkinson’s disease” and “Healthy Control” were included.
Data are No. (%), or median (range). The reported p-values represent the significance from corresponding Kruskal–Wallis Tests.
DeNoPa = De Novo Parkinson Study. PPMI = Parkinson’s Progression Marker Initiative. FOUND = Follow Up Persons with Neurologic Disease Study. MDS = International Parkinson and Movement Disorder Society. UPDRS = Unified Parkinson’s Disease Rating Scale. n.a. not available.