Table 2.

Primary analysis, multiple linear regression estimates, and average-based optimism-adjusted R²

Coefficient	Estimate	Std. error	Pr ( >|t|)	95% CI lower bound	95% CI upper bound	Bootstrap CI lower bound	Bootstrap CI Upper bound
Intercept	2.178	0.172	< 0.001***	1.843	2.500	1.870	2.497
CYP2D6
IM/PM	0.275	0.178	< 0.001***	0.034	0.492	0.034	0.487
IM/IM	0.734	0.152	< 0.001***	0.424	1.029	0.404	1.033
NM/PM	1.060	0.149	< 0.001***	0.867	1.221	0.910	1.202
NM/IM	1.116	0.152	< 0.001***	0.937	1.283	0.965	1.263
NM/NM	1.375	0.170	< 0.001***	1.208	1.536	1.220	1.506
Age	0.006	0.002	< 0.001***	0.003	0.010	0.003	0.012
Weight	− 0.005	0.002	0.002**	− 0.007	− 0.002	− 0.008	− 0.002
Adjusted R2	0.571					0.491	0.635

Pr ( >|t|), probability of observing any value equal or larger than t; CI, confidence interval; *, p-value < 0.05; **, p-value < 0.01; ***, p-value < 0.001; NM, normal metabolizer; IM, intermediate metabolizer; PM, poor metabolizer