Table 3.

Sensitivity analysis and complete case analysis

Coefficient	Estimate	Std. error	Pr ( >|t|)	95% CI lower bound	95% CI upper bound	Bootstrap CI Lower bound	Bootstrap CI Upper bound
Intercept	2.178	0.172	< 0.001***	1.839	2.517	1.884	2.465
CYP2D6
IM/PM	0.275	0.124	< 0.027*	0.031	0.519	0.045	0.459
IM/IM	0.734	0.162	< 0.001***	0.414	1.053	0.435	0.982
NM/PM	1.060	0.090	< 0.001***	0.890	1.234	0.888	1.183
NM/IM	1.116	0.090	< 0.001***	0.942	1.291	0.960	1.251
NM/NM	1.374	0.084	< 0.001***	1.207	1.542	1.232	1.505
Age	0.006	0.001	0.001**	0.002	0.010	0.003	0.010
Weight	− 0.005	0.001	0.002**	− 0.008	− 0.001	− 0.008	− 0.002
Adjusted R2	0.556					0.469	0.641

Pr ( >|t|), probability of observing any value equal or larger than t

CI confidence interval; NM normal metabolizer; IM intermediate metabolizer; PM poor metabolizer

*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001