Table 4.
Logistic regression for subtherapeutic endoxifen levels (< 16 nmol/L)
| Coefficient | Estimate | Standard error | Pr ( >|t|) | 95% CI Lower bound | 95% CI Upper bound | Bootstrap CI lower bound | Bootstrap CI upper bound |
|---|---|---|---|---|---|---|---|
| Intercept | − 2.088 | 1.050 | 0.04* | − 4.267 | − 0.110 | − 17.029 | − 0.146 |
| CYP2D6 | |||||||
| NM/IM | 1.717 | 0.690 | 0.01* | 0.460 | 3.256 | 0.143 | 3.396 |
| NM/PM | 1.793 | 0.680 | 0.008** | 0.559 | 3.321 | 0.153 | 3.500 |
| IM/IM | 3.950 | 0.946 | < 0.001*** | 2.182 | 5.978 | − 0.099 | 20.908 |
| IM/PM | 5.780 | 0.965 | < 0.001*** | 4.108 | 7.990 | 3.825 | 22.310 |
| PM/PM | 22.223 | 1293.752 | 0.986 | − 24.296 | 496.5 | 20.370 | 24.420 |
| Age | − 0.028 | 0.017 | 0.10 | − 0.062 | − 0.005 | − 0.056 | 0.001 |
Pr ( >|t|), probability of observing any value equal or larger than t
CI confidence interval; NM normal metabolizer; IM intermediate metabolizer; PM poor metabolizer
*p-value < 0.05; **p-value < 0.01; ***p-value < 0.001