Table 2.
ADCOMS scores by clinical group at baseline
| Group | n | Mean | SD | Observed range (min–max) |
Floor n(%) |
Ceiling n(%) |
|---|---|---|---|---|---|---|
| Normal cognition | ||||||
| All | 1825 | 0.06 | 0.04 | 0.00–0.48 | 7 (0.4%) | 0 (0.0%) |
| APOE ε4 carrier | 542 | 0.06 | 0.04 | 0.00–0.34 | 3 (0.6%) | 0 (0.0%) |
| APOE ε4 non-carrier | 1198 | 0.05 | 0.03 | 0.00–0.48 | 4 (0.3%) | 0 (0.0%) |
| Impaired (not-MCI) | ||||||
| All | 117 | 0.15 | 0.09 | 0.04–0.48 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 carrier | 38 | 0.17 | 0.09 | 0.04–0.38 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 non-carrier | 67 | 0.14 | 0.08 | 0.04–0.48 | 0 (0.0%) | 0 (0.0%) |
| MCI | ||||||
| All | 2001 | 0.22 | 0.11 | 0.03–0.75 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 carrier | 885 | 0.24 | 0.11 | 0.04–0.75 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 non-carrier | 890 | 0.21 | 0.11 | 0.03–0.71 | 0 (0.0%) | 0 (0.0%) |
| Dementia | ||||||
| All | 1412 | 0.64 | 0.34 | 0.04–2.01 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 carrier | 712 | 0.63 | 0.30 | 0.09–2.01 | 0 (0.0%) | 0 (0.0%) |
| APOE ε4 non-carrier | 560 | 0.62 | 0.33 | 0.04–2.01 | 0 (0.0%) | 0 (0.0%) |
ADCOMS Alzheimer’s Disease Composite Score, MCI mild cognitive impairment, SD standard deviation
APOE ε4 carrier status is missing for n = 463 participants