. 2022 May 5;11(3):1085–1100. doi: 10.1007/s40120-022-00352-w

Table 6.

Anchor-based analysis: ADCOMS score change from baseline to month 12 CDR-SOB change score responder group, stratified by APOE ε4 carrier status for dementia patients

ADCOMS change score^a	Total N	Changes in CDR-SOB^b		Mean Difference (95% CI)	t-test	p-value^c
ADCOMS change score^a	Total N	No meaningful decline n Mean (SD)	Meaningful decline n Mean (SD)	Mean Difference (95% CI)	t-test	p-value^c
APOE ε4 carrier
NACC	607	259 – 0.007 (0.113)	348 0.301 (0.215)	– 0.308 (– 0.334; – 0.281)	– 22.79	< 0.0001
ADNI	105	44 0.033 (0.097)	61 0.309 (0.239)	– 0.275 (– 0.342; – 0.208)	– 8.11	< 0.0001
APOE ε4 non-carrier
NACC	506	224 – 0.019 (0.123)	282 0.325 (0.234)	– 0.344 (– 0.376; – 0.312)	– 21.25	< 0.0001
ADNI	54	21 0.041 (0.115)	33 0.284 (0.193)	– 0.243 (– 0.327; – 0.158)	– 5.78	< 0.0001

ADCOMS Alzheimer’s Disease Composite Score, ADNI Alzheimer’s Disease Neuroimaging Initiative, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, CI confidence interval, NACC National Alzheimer’s Coordinating Center, SD standard deviation

^aChange score = month 12 score – baseline score

^bMeaningful decline: CDR-SOB change ≥ 1.0 from baseline to month 12

^ct-test