Table 7.

Triangulation table for meaningful change for MCI and dementia patients

	MCI	Dementia
Anchor-based Approach (CDR-SOB)
ROC analysis	0.02–0.05	0.11–0.15
Mean differencea	0.17–0.20	0.26–0.33
Median changeb	0.14	0.26
Distribution-based approach
0.25*SD	0.02–0.03	0.05–0.09
0.5*SD	0.05–0.06	0.09–0.17
SEM	0.04–0.05	0.08–0.10

The range of values presented for MCI is from the three data sources (ADNI, NACC, pooled data). The range of values presented for dementia is from the two data sources (ADNI, NACC)

ADCOMS Alzheimer’s Disease Composite Score, ADNI Alzheimer’s Disease Neuroimaging Initiative, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, MCI mild cognitive impairment, NACC National Alzheimer’s Coordinating Center, SD standard deviation, ROC receiver-operating characteristic, SEM standard error of measurement

^aMean difference between change in ADCOMS scores (from baseline to month 12) for patients with no meaningful decline vs. meaningful decline at month 12 (defined by CDR-SOB ≥ 0.5 for MCI; CDR-SOB ≥ 1 for dementia)

^bMedian change in ADCOMS score among those who had meaningful decline on the CDR-SOB (defined by CDR-SOB ≥ 0.5 for MCI; CDR-SOB ≥ 1 for dementia)