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. 2022 Jul 29;12:13027. doi: 10.1038/s41598-022-17190-3

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Normalized within-network connectivity estimates for significant interactions between AUDIT group and rs6923761 genotype. Top panels (brain images) include the component T-map extracted during the ICA processing step; colors represent T-max values. High-AUDIT: AUDIT total score ≥ 8 (n = 96); Low-AUDIT: AUDIT total score < 8 (n = 85). A is the risk allele; A-allele carriers: AA + AG (n = 65); Non-A-allele carriers: GG (n = 116). IC35 (insula; A) and IC47 (frontal/acc/putamen; B) were mapped onto the anterior salience network; IC21 (insula/occipital/mpfc; C) was mapped onto the visuospatial network.