Fig. 3.

Biological sex influences baseline cardiac metabolite abundances. Unbiased metabolomics of male and female sedentary mice. (A) Dot plot showing 69 significantly different (FDR < 0.10) metabolites between male and female hearts; (B) Partial least-squares discriminant analysis; and (C) Variable importance plot assessing metabolite contribution to the PLS-DA model. n = 4–5 mice per group. F = female; FDR = false discovery rate; GPE = glycerophosphoethanolamine; M = male; mz = mass to charge ratio; PLS-DA = partial least-squares discriminant analysis; rt = retention time; VIP = variable importance plot.