Fig. 1.

LncRNAs participate in the regulation of OCT4 expression through multiple mechanisms. A. LncRNAs including Oct4-pg4 binding to the OCT4 gene promoter change the degree of local methylation. Oplr16 mediates the formation of the intrachromosomal loop and gathers OCT4 cis-acting elements scattered in different parts of chromosomes. B. LncRNAs including DANCR inhibit OCT4 downregulation at the posttranscriptional level by competing with OCT4 mRNA to bind miRNAs. C. LncRNAs including MIAT and OCT4 regulate each other's expression through a feedback loop. D. LncRNAs including NEAT1 are a downstream molecule of OCT4. E. LncRNAs including PSORS1C3 share a promoter with OCT4