Table 1.
Summary of OCT4 associated lncRNAs
| LncRNA | Location (Human) | Mechanism | Cell line | Nude mice xenograft tumour model | Human sample | Refs. |
|---|---|---|---|---|---|---|
| mmu-OCT4-pg4 | Mice | RNA-binding protein FUS; Histone methyltransferase SUV39H1 | mice ESC cell(Isolated from C57BL/6 mouse embryos) | – | – | [13, 14] |
| hsa-OCT4-pg3 | 12p13.31 | Same as above | OVACR-3 | – | – | [14] |
| mmu-OCT4-pg5 | Mice | Histone methyltransferase Ezh2 |
Breast cancer cell line: MCF-7 |
– | – | [15] |
| CCAT2 | 8q24.21 | OCT4-pg1; miR-205 |
Breast cancer cell line: MCF-7, MDA-MB-231, etc. |
MDA-MB-231 | Breast cancer | [16] |
| Oplr16 | Mice | Intrachromosomal loop; DNA demethylase TETs | iPSC (reprogramed from mice fibroblast by OSKM) | – | – | [20] |
| Osblr8 | Mice | Same as above | iPSC (same as above), mice ESC cell line E14 | – | – | [21] |
| Peblr20 | Mice | Same as above | iPSC(same as above) | – | – | [22] |
| DANCR | 4q12 |
miR-216a-5p; miR-335; miR-145 |
Breast cancer cell line: MCF-7, MDA-MB-231, etc.; urothelium cell line SV-HUC-1 |
MDA-MB-231 | Breast cancer | [5–7, 23] |
| SLCO4A1-AS1 | 20q13.33 | miR-335-5p | Bladder cancer cell lines: EJ, T24 andRT4; | T24 | Bladder cancer | [8] |
| Linc00337 | 1p36.31 | miR-145 | Cervical cancer cell lines: HeLa, SiHa, CaSki, etc.; sphere-forming subpopulation isolated from HeLa cells | sphere-forming subpopulation | Cervical cancer | [9] |
| LincRNA-ROR | 18q21.31 | miR-145 | CD44+/CD133+ subpopulation isolated from Prostate cancer cell lines Du145 and 22RV1 | CD44+/CD133+ subpopulation | Prostate cancer | [24, 25] |
| SNHG3 | 1p35.3 | miR-3619-5p | Gastric cancer cell lines SGC7901 and BGC823; mice ESC cell line AB2.2 | – | Gastric cancer | [27, 28] |
| SNHG7 | 9q34.3 | miR-34a |
Breast cancer cell line: MCF-7, MDA-MB-231, etc. |
– | Breast cancer | [29, 30] |
| SNHG20 | 17q25.2 | miR-197, Lin28 | Oral squamous cell carcinoma cell lines SCC9, SCC15, SCC25, etc. | SCC15 | Oral squamous cell carcinoma | [31] |
| LX8-SINE B2 | Mice | Regulated by OCT4 | mice ESC cell line E14 | – | – | [32] |
| NEAT1 | 11q13.1 | Regulated by OCT4; miR-204-5p | Lung cancer cell lines A549 and CL1-0; Bladder cancer cell line T24 | Ovariectomized obese mouse model induced by high fat diet | Lung cancer | [10, 33] |
| ES1 | 6p23 | mutually regulated with OCT4 | 人Breast cancer cell line: MDA-MB-231, SKBR3, etc. | – | Breast cancer | [34, 35] |
| MIAT | 22q12.1 | Same as above |
mice ESC cell line E14; Leukaemia/Lymphoma cell lines BALL, DLBL, etc. Breast cancer cell line: MCF-7, MDA-MB-231, etc. |
– | Leukaemia; Breast cancer | [37–39] |
| MALAT1 | 11q13.1 | Same as above | Lung cancer cell lines A549 and CL1-0; Colorectal cancer cell lines COLO205, HCT‐116, etc. | HCT‐116 | Lung cancer | [10, 41] |
| PSORS1C3 | 6p21.33 | Share promotor with OCT4 | Teratoma cell line NT2; A549; Kidney cancer cell lines CRL-1932/1611 | – | Clear cell carcinoma of kidney | [44–46] |