Table 3.

Subgroup analysis

Medication	New MC vs. No MC		Registry MC vs. No MC
	Odds Ratio (95% CI)	p-val	Odds ratio (95% CI)	p-val
Any dose aspirin	2.36 (0.78–7.21)	0.11	2.80 (1.25–6.02)	< 0.01
Other NSAIDs	2.91 (1.04–7.87)	0.03	2.56 (1.26–5.16)	< 0.01
Any aspirin or NSAIDs	2.70 (1.04–7.36)	0.03	3.02 (1.55–6.07)	< 0.01
PPIs	0.69 (0.20–2.15)	0.53	0.91 (0.42–1.92)	0.81
H2RAs	1.42 (0.06–11.59)	0.56	2.62 (0.68–10.73)	0.16
SSRIs	1.17 (0.41–3.38)	0.76	1.62 (0.81–3.29)	0.16
Statins	0.84 (0.27–2.53)	0.75	1.09 (0.52–2.25)	0.81
ACE-Is	0.35 (0.02–2.44)	0.47	0.24 (0.04–1.08)	0.06
ARBs	1.45 (0.21–6.96)	0.64	0.43 (0.10–1.58)	0.25

P-values and odds ratios (OR) were calculated comparing rate of medication use among the two groups of microscopic colitis (MC) patients independently compared to the no-MC group to assess homogeneity of findings. 95% CI: 95% Confidence Interval, NSAIDs: non-steroidal anti-inflammatory drugs, PPIs: proton pump inhibitors, H2RAs: histamine-2 receptor antagonists, SSRIs: selective serotonin reuptake inhibitors, ACE-Is: angiotensin converting enzyme inhibitors, ARBs: angiotensin receptor blockers