TABLE 1.
Sample Characteristics
| MS | Healthy Controls | |
|---|---|---|
| Sample Size1 | 185 | 50 |
| Age (mean ± sd) | 34.4±7.5 | 32.9±7.5 |
| Sex (F/M) | 123/62 | 32/18 |
| Verbal IQ (mean ± sd) | 108.2±9.2 | 111.0±9.3 |
| MHI-5 (mean ± sd) | 71.0±17.5 | 74.2±14.2 |
| BDI-FS median (IQR) | 2.0 (0.0–4.0) | 1.0 (0.0–3.0) |
| Disease Course (RRMS / CIS)24 | 165 / 20 | |
| Years since Diagnosis (mean ± sd) | 2.1 ± 1.3 (median=2.0) | |
| Years since 1st Symptom | 3.4 ± 2.8 (median=2.8) | |
| EDSS (median; IQR) | 1.0; 0.0–1.5 |
1
Two enrolled patients were not permitted to undergo research MRIs due to metal in their bodies. These patients had not reported this contraindication prior to enrollment because the metal had not precluded previous clinical MR imaging. The sample size for imaging analyses was therefore 183. There were no significant differences between patients and controls in age, sex, or estimated premorbid verbal IQ. BDI-FS scores were higher among patients than controls (p=.035), but MHI-5 scores did not differ between groups (p>.10).