Table 3.
Tumor response, surgical outcome, pathologic response, and chemotherapy response score with NACT/GEN-1 escalating doses.
| Cohort 1 | Cohort 2 | Cohort 3 | Cohort 4 | |||
|---|---|---|---|---|---|---|
| Radiographic response | Total (n) | 36 mg/m2 | 47 mg/m2 | 61 mg/m2 | 79 mg/m2 | |
| Tumor response | CR | 2 | 1 | 0 | 0 | 1 |
| PR | 10 | 0 | 3 | 3 | 4 | |
| SD | 2 | 2 | 0 | 0 | 0 | |
| Objective response rate | 67% | 100% | ||||
| Surgical outcome | R0 | 9 | 2 | 0 | 2 | 5 |
| R1 | 3 | 1 | 2 | 0 | 0 | |
| R2 | 2 | 0 | 1 | 1 | 0 | |
| R0 resection rate | 33% | 88% | ||||
| Pathologic response | cPR | 1 | 1 | 0 | 0 | 0 |
| Micro | 8 | 1 | 2 | 1 | 4 | |
| Macro | 5 | 1 | 1 | 2 | 1 | |
| cPR/micro rate | 60% | 63% | ||||
| Chemotherapy | CRS 3 | 5 | 1 | 0 | 2 | 2 |
| Response | CRS 2 | 5 | 2 | 1 | 0 | 2 |
| Score | CRS 1 | 4 | 0 | 2 | 1 | 1 |
| CRS 3 rate | 17% | 50% | ||||