Fig. 2.

Gene set enrichment analysis derived from ciliated cells in mild/moderate COVID-19 patients vs. healthy controls

The Figure illustrates a network of GO (Gene Ontology) terms corresponding to biological processes (BPs) significantly enriched in genes upregulated (blue nodes) and downregulated (red nodes) in mild-moderate COVID-19 (COVID-M) patients concerning to healthy control (HC) individuals (Bonferroni adjusted p-value, FDR 0.05). The node's size is proportional to the number of genes associated with that BP. The edges represent gene overlap between gene sets related to different GO terms. Connected nodes are organized in clusters of interconnected BPs obtained by the MCL algorithm, which considers similarity among gene sets to assign the edges, with a similarity score threshold of 0.5.