Fig. 6.

Network of the 336 genes downregulated in COVID-S and their associated GO terms for biological processes (BP)

The network was constructed using the ToppGene/ToppCluster resource (https://toppgene.cchmc.org/) with an FDR of 0.05. Hexagons in red and squares in light blue stand for genes and BPs, respectively, which were distributed using the edge-weighted Spring embedded layout and slightly modified for readability using Cytoscape v3.4.0. In general, the upper left region shows BP associated with DNA and histone modifications, regulation of transcription, and chromatin or chromosome remodelling. In contrast, the right middle part shows BPs associated with organ morphogenesis, particularly cardiac and vascular. The lower left region shows metabolic processes, primarily catabolic.