Figure 4.

Effects of LIFU stimulation on the ACC in chronic neuropathic pain (CNP) model mice. 50% mechanical withdrawal threshold (MWT₅₀) significantly decreased in the CCI and CCI+LIFU groups after CCI surgery when compared with the sham group until the end of the study. After 21 days of LIFU treatment, the MWT₅₀ increased when compared with the CCI group. Each symbol represents the mean ± SEM; ^#P < 0.05 compared with the CCI and CCI+LIFU groups; ^∗P < 0.05 compared with the sham group. Two-way repeated-measures ANOVA, followed by the Bonferroni test; n = 10 per group.