Table 6.

Dermal toxicity assessment of P. clappertoniana fruit husk extract- (PCFHE-) reconstituted wound healing formula (RWHF) topically applied to shaved skin areas of rats.

Animal	Period after treatment					Erythema index	Oedema index
	0 h	6 h	24 h	48 h	72 h
1	No behavioral change, i.e., in locomotion, no defecation,	No behavioral change during their normal activities—feeding and drinking water	No sign of oedema, erythema	No sign of oedema, erythema	No sign of oedema, erythema	0	0
2	No behavioral change, i.e., in locomotion, no defecation	No behavioral change during their normal activities—feeding and drinking water	No sign of oedema, erythema	No sign of oedema, erythema	No sign of oedema, erythema	0	0
3	No behavioral change, i.e., in locomotion, no defecation	No behavioral change during their normal activities—feeding and drinking water	No sign of oedema, erythema	No sign of oedema, erythema	No sign of oedema, erythema	0	0
Positive control 1 g (NaOH)	No behavioural change, i.e., in locomotion, no defecation	No behavioural change during their normal activities—feeding and drinking water	Oedema, erythema seen	Oedema, erythema seen	Oedema, erythema seen	4	2

No erythema/no oedema = 0; very light erythema (barely perceptible)/very light oedema (barely perceptible) = 1; well-defined erythema/slight oedema (edges of area well-defined by definite raising) = 2; moderate to severe erythema/moderate oedema (raised approximately 1 mm) = 3; severe erythema (beef redness)/(extending beyond the area of exposure) = 4; P. clappertoniana fruit husk extract (PCFHE).