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. 2022 May 28;39(4):679–689. doi: 10.1007/s10585-022-10166-7

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effects of minoxidil (MIN), ranolazine (RAN) and their combination on invasiveness of MDA-MB-231 cells: Comparison of hypoxic and normoxic conditions. Box plots showing the effects of 2.5 µM MIN, 2.5 µM RAN and combination treatments on cell invasiveness under A hypoxia and B normoxia (n = 3 for both). The Y-axis represents invasion normalized to the largest number of invaded cells viewed per insert. The box plots are presented as medians, interquartile range; 5% and 95% confidence intervals and outliers. Statistical significance is shown as; ***P < 0.001