Fig. 4.

Dose-dependent effects of minoxidil (MIN) and ranolazine (RAN) and their combination on invasion under hypoxia and comparison with normoxia. Graphs showing the effects of A 0.625–5 µM RAN and the combination with 2.5 µM MIN and B 2.5–50 µM MIN and the combination with 5 µM RAN on reducing cell invasiveness under hypoxia. Also shown are effects of A 2.5 µM RAN and B 2.5 µM MIN on cell invasiveness under normoxia. The Y-axis represents the percentage reduction in invasion. The data are presented as means ± standard error of the means. Data are from n = 6–14 experimental repeats